{"id":6167,"date":"2023-12-29T11:26:32","date_gmt":"2023-12-29T03:26:32","guid":{"rendered":"https:\/\/xiaguangshe.com\/?p=6167"},"modified":"2023-12-29T11:26:32","modified_gmt":"2023-12-29T03:26:32","slug":"%e5%90%af%e8%88%aa%e5%87%ba%e6%b5%b7%ef%bc%8c%e5%a4%8d%e5%ae%8f%e6%b1%89%e9%9c%96h%e8%8d%af%e4%ba%8e%e5%8d%b0%e5%ba%a6%e5%b0%bc%e8%a5%bf%e4%ba%9a%e8%8e%b7%e6%89%b9%e4%b8%8a%e5%b8%82","status":"publish","type":"post","link":"https:\/\/xiaguangshe.com\/en\/6167\/","title":{"rendered":"\u542f\u822a\u51fa\u6d77\uff0c\u590d\u5b8f\u6c49\u9716H\u836f\u4e8e\u5370\u5ea6\u5c3c\u897f\u4e9a\u83b7\u6279\u4e0a\u5e02"},"content":{"rendered":"<ul type=\"disc\">\n<li>\u9996\u4e2a\u5728\u4e1c\u5357\u4e9a\u56fd\u5bb6\u6210\u529f\u83b7\u6279\u4e0a\u5e02\u7684\u56fd\u4ea7\u6297PD-1\u5355\u6297\uff1b<\/li>\n<li>H\u836f\u9996\u6b21\u5728\u6d77\u5916\u6210\u529f\u83b7\u6279\u4e0a\u5e02\uff0c\u662f\u7ee7\u6c49\u66f2\u4f18<sup>\u00ae<\/sup>\u4e4b\u540e\u516c\u53f8&#8221;\u56fd\u9645\u5316\u6218\u7565&#8221;\u53c8\u4e00\u91cd\u5927\u6210\u679c\uff1b<\/li>\n<li>\u643a\u624bKGbio\u7b49\u5408\u4f5c\u4f19\u4f34\uff0c\u5f00\u62d3\u8d85\u8fc770\u4e2a\u56fd\u5bb6\u548c\u5730\u533a<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e7412\u670828\u65e5<\/span>\u00a0\/\u7f8e\u901a\u793e\/ &#8212; 2023\u5e7412\u670828\u65e5\uff0c\u590d\u5b8f\u6c49\u9716\uff082696.HK\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5546\u4e1a\u5408\u4f5c\u4f19\u4f34PT Kalbe Genexine Biologics\uff08KGbio\uff09\u9644\u5c5e\u516c\u53f8PT Kalbio Global Medika\u6536\u5230\u836f\u54c1\u6ce8\u518c\u6279\u4ef6\uff0c\u590d\u5b8f\u6c49\u9716\u81ea\u4e3b\u7814\u53d1\u548c\u751f\u4ea7\u7684\u6297PD-1\u5355\u6297H\u836f 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(EMA) \u53d7\u7406\u3002\u6b64\u5916\uff0c\u516c\u53f8\u7a33\u6b65\u63a8\u8fdbH\u836f\u5bf9\u6bd4\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u963f\u66ff\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597ES-SCLC\u7684\u5934\u5bf9\u5934\u7f8e\u56fd\u6865\u63a5\u8bd5\u9a8c\uff0c\u4ee5\u8fdb\u4e00\u6b65\u652f\u6301H\u836f\u5728\u7f8e\u56fd\u7684\u4e0a\u5e02\u7533\u62a5\u3002<\/p>\n<p>\u51ed\u501f\u7a81\u7834\u6027\u7597\u6548\u548c\u5dee\u5f02\u5316\u4f18\u52bf\uff0cH\u836f\u5c55\u73b0\u51fa\u4e86\u5f3a\u5927\u7684\u5e02\u573a\u7ade\u4e89\u529b\uff0c\u83b7\u5f97\u4e86\u4e1a\u5185\u5e7f\u6cdb\u8ba4\u53ef\uff0c\u5176\u591a\u9879\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u4e8e\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b\uff08<i><span id=\"spanHghlt3b35\">JAMA<\/span><\/i>\uff09\u3001<i><span id=\"spanHghltea24\">Nature Medicine<\/span><\/i>\u7b49\u56fd\u9645\u77e5\u540d\u671f\u520a\u3002\u590d\u5b8f\u6c49\u9716\u79ef\u6781\u63a8\u8fdbH\u836f\u4e0e\u516c\u53f8\u5176\u4ed6\u4ea7\u54c1\u7684\u534f\u540c\u4ee5\u53ca\u4e0e\u521b\u65b0\u7597\u6cd5\u7684\u8054\u5408\uff0c\u5728\u5168\u7403\u540c\u6b65\u5f00\u5c55\u5341\u4f59\u9879\u80bf\u7624\u514d\u75ab\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e7f\u6cdb\u8986\u76d6\u80ba\u764c\u3001\u98df\u7ba1\u764c\u548c\u80c3\u764c\u7b49\u9002\u5e94\u75c7\uff0c\u5168\u9762\u8986\u76d6\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\uff0c\u5168\u7403\u7d2f\u8ba1\u5165\u7ec4\u60a3\u8005\u8d853600\u4eba\u3002<\/p>\n<p>2019\u5e74\uff0c\u590d\u5b8f\u6c49\u9716\u4e0eKGbio\u5c31H\u836f\u7b7e\u8ba2\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae\uff0c\u6388\u4e88\u5176H\u836f\u5728\u4e1c\u76df\u5341\u56fd\u7684\u90e8\u5206\u9002\u5e94\u75c7\u53ca\u7597\u6cd5\u7684\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u30022023\u5e748\u6708\uff0c\u516c\u53f8\u8fdb\u4e00\u6b65\u6269\u5927\u4e0eKGbio\u7684\u5408\u4f5c\uff0c\u6388\u4e88\u5176\u5728\u6c99\u7279\u963f\u62c9\u4f2f\u3001\u963f\u8054\u914b\u3001\u57c3\u53ca\u3001\u5361\u5854\u5c14\u3001\u7ea6\u65e6\u3001\u6469\u6d1b\u54e5\u7b4912\u4e2a\u4e2d\u4e1c\u548c\u5317\u975e\u5730\u533a\uff08MENA\uff09\u56fd\u5bb6\u9488\u5bf9H\u836f\u5305\u62ecES-SCLC\u5728\u5185\u7684\u4e24\u9879\u9002\u5e94\u75c7\u8fdb\u884c\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u6743\u76ca\u3002\u672a\u6765\uff0c\u590d\u5b8f\u6c49\u9716\u4e5f\u5c06\u643a\u624bKGbio\u548c\u5176\u5b83\u5408\u4f5c\u4f19\u4f34\u6301\u7eed\u63a8\u52a8H\u836f\u5728\u66f4\u591a\u56fd\u5bb6\u7684\u83b7\u6279\u4e0a\u5e02\u8fdb\u7a0b\u3002<\/p>\n<p>\u5173\u4e8eH\u836f 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\u6c49\u65af\u72b6<sup>\u00ae<\/sup>\u4e3a\u91cd\u7ec4\u4eba\u6e90\u5316\u6297PD-1\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u901a\u7528\u540d\uff1a\u65af\u9c81\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u5168\u7403\u9996\u4e2a\u83b7\u6279\u4e00\u7ebf\u6cbb\u7597\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6297PD-1\u5355\u6297\uff0c\u5df2\u5728\u4e2d\u56fd\u548c\u5370\u5ea6\u5c3c\u897f\u4e9a\u83b7\u6279\u4e0a\u5e02\u3002\u622a\u81f3\u76ee\u524d\uff0cH\u836f\u5df2\u67094\u9879\u9002\u5e94\u75c7\u83b7\u6279\u4e0a\u5e02\uff0c2\u9879\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u5206\u522b\u5728\u4e2d\u56fd\u548c\u6b27\u76df\u83b7\u53d7\u7406\uff0c10\u4f59\u9879\u4e34\u5e8a\u8bd5\u9a8c\u540c\u6b65\u5728\u5168\u7403\u5f00\u5c55\u3002<\/p>\n<p>2022\u5e743\u6708\uff0cH\u836f\u6b63\u5f0f\u4e8e\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u76ee\u524d\u53ef\u7528\u4e8e\u6cbb\u7597\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff08MSI-H\uff09\u5b9e\u4f53\u7624\u3001\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08sqNSCLC\uff09\u3001\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09\u53ca\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u3002H\u836f\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08nsNSCLC\uff09\u548c\u4e00\u7ebf\u6cbb\u7597\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09\u7684\u4e0a\u5e02\u7533\u8bf7\u4e5f\u5206\u522b\u83b7\u5f97\u4e2d\u56fdNMPA\u548c\u6b27\u76dfEMA\u53d7\u7406\u3002\u805a\u7126\u80ba\u764c\u548c\u6d88\u5316\u9053\u80bf\u7624\uff0c\u590d\u5b8f\u6c49\u9716\u79ef\u6781\u63a8\u8fdbH\u836f\u4e0e\u516c\u53f8\u5176\u4ed6\u4ea7\u54c1\u7684\u534f\u540c\u4ee5\u53ca\u4e0e\u521b\u65b0\u7597\u6cd5\u7684\u8054\u5408\uff0c\u5728\u5168\u7403\u540c\u6b65\u5f00\u5c5510\u4f59\u9879\u80bf\u7624\u514d\u75ab\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e8e\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u571f\u8033\u5176\u3001\u6ce2\u5170\u3001\u683c\u9c81\u5409\u4e9a\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u7d2f\u8ba1\u5165\u7ec4\u8d853600\u4eba\u3002H\u836f\u76843\u9879\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u5206\u522b\u53d1\u8868\u4e8e\u77e5\u540d\u671f\u520a\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b\uff08<i><span id=\"spanHghltbc05\">JAMA<\/span><\/i>\uff09\u3001\u300a\u81ea\u7136-\u533b\u5b66\u300b\uff08<i><span id=\"spanHghlt3a06\">Nature Medicine<\/span><\/i>\uff09\u548c<i><span id=\"spanHghltef9b\">British Journal of Cancer<\/span><\/i>\u3002\u6b64\u5916\uff0cH\u836f\u8fd8\u8363\u83b7\u300aCSCO \u5c0f\u7ec6\u80de\u80ba\u764c\u8bca\u7597\u6307\u5357\u300b\u3001\u300aCSCO\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8bca\u7597\u6307\u5357\u300b\u3001\u300aCSCO \u98df\u7ba1\u764c\u8bca\u7597\u6307\u5357\u300b\u3001\u300aCSCO\u7ed3\u76f4\u80a0\u764c\u8bca\u7597\u6307\u5357\u300b\u3001\u300aCSCO\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e34\u5e8a\u5e94\u7528\u6307\u5357\u300b\u548c\u300a\u4e2d\u56fd\u98df\u7ba1\u764c\u653e\u5c04\u6cbb\u7597\u6307\u5357\u300b\u7b49\u591a\u90e8\u6743\u5a01\u6307\u5357\u63a8\u8350\uff0c\u4e3a\u80bf\u7624\u4e34\u5e8a\u8bca\u7597\u63d0\u4f9b\u91cd\u8981\u53c2\u8003\u3002\u6d77\u5916\u65b9\u9762\uff0cH\u836f\u6cbb\u7597SCLC\u4e5f\u5df2\u83b7\u5f97\u7f8e\u56fdFDA\u548c\u6b27\u76dfEC\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u5e76\u5728\u7f8e\u56fd\u542f\u52a8\u4e86\u4e00\u9879H\u836f\u5bf9\u6bd4\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u5934\u5bf9\u5934\u6865\u63a5\u8bd5\u9a8c\u3002<\/p>\n<div>\n<table class=\"prnbcc\" border=\"0\" cellspacing=\"0\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u3010\u53c2\u8003\u6587\u732e\u3011<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and MortalityWorldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]Eskandar A, Ahmed A, Daughtey M, et al. Racial and sex differences in presentation and outcomes of small cell lung cancer in the United States: 1973 to 2010[J].Chest, 2015,147(4): e164-e165.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]Klautke G , Sauer R, Fietkau R .Combined Treatment Modality in Small Cell Lung Cancer[J]. Strahlentherapie Und Onkologie, 2008, 184(2):61-66.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[4]Puglisi M , Dolly S , Faria A , et al. Treatment options for small cell lung cancer \u2013 do we have more choice?[J].Br J Cancer, 2010, 102(4):629-638.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9996\u4e2a\u5728\u4e1c\u5357\u4e9a\u56fd\u5bb6\u6210\u529f\u83b7\u6279\u4e0a\u5e02\u7684\u56fd\u4ea7\u6297PD-1\u5355\u6297\uff1b H\u836f\u9996\u6b21\u5728\u6d77\u5916\u6210\u529f\u83b7\u6279\u4e0a\u5e02\uff0c\u662f\u7ee7\u6c49\u66f2\u4f18\u00ae\u4e4b\u540e\u516c\u53f8&#038;#822 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5825,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[410],"tags":[],"class_list":["post-6167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reprint"],"_links":{"self":[{"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/posts\/6167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/comments?post=6167"}],"version-history":[{"count":0,"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/posts\/6167\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/media\/5825"}],"wp:attachment":[{"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/media?parent=6167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/categories?post=6167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xiaguangshe.com\/en\/wp-json\/wp\/v2\/tags?post=6167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}